The Neofluidics platform technology enables high throughput model organism studies for disease research and drug screening
Microfluidics tools have emerged as a useful way to study model organisms like zebrafish, drosophila, or C. elegans.
NeoMO™ is a line of microfluidic devices that allows easier growing and screening of model organisms:
With a unique, patented design for on-chip trapping, immobilization and culture of embryos and worms
No agar, anesthesia or glues are required
Load organisms easily by using regular or multichannel pipettes
Ability to document experiments using high-resolution imaging
Reduced reagent needed
Excellent control of the environment
Accurate and controlled flow rate for drugs or chemical stimuli being tested
What sets the NeoMO™ product line apart?
Quick and simple organism loading
On device dechorionation functionality
Anesthetic- and agar-free interventions
Continuous alignment in the same focal plane for hassle-free imaging
Manual operation or compatible with robotic liquid handlers
Transient or continuous perfusion
Current solutions have complex, time and labor-intensive workflows. Neofluidics eliminates these hassles.
Zebrafish (Danio rerio) is a powerful, robust, and relevant small animal model for drug discovery and development. It is a holistic and target agonistic vertebrate model that can be used at different life-stages. It is used to study disease intervention and activation, transport and efficacy of chemicals, toxicity and other pharmacological effects.
Zebrafish is a widely-accepted model for new drug discovery platforms because of the following:
(a) >70% human equivalent genes
(b) multiorgan vertebrate
(c) short generation time (2-3 months)
(d) rapid transparent growth
(e) high reproduction rate
(f) easy genetic manipulation
(g) small size, high throughput screening (HTS) capability
(h) cheaper animal model compared to mice.
Despite these advantages, there are several bottlenecks, which need to be alleviated to make Zebrafish serve as the Perfect 3R: refinement, reduction and replacement of conventional preclinical models including:
(a) complex, time- and labor-intensive protocols
(b) larvae are light-sensitive, highly motile, difficult to localize, orient, and align for imaging
(c) manual chorion removal is time consuming and requires expertise
The NeoMO™ product line includes devices customized for easy culture of zebrafish up to 3 weeks post fertilization.
Compared to the solutions available today, mZMount™ μ offers huge benefits in ease of use, functionality, and cost-effectivenes